Document Type

Article

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Published by Wiley in FEMS Microbiology Letters Volume 234, Issue 2, pages 343-348.

Publication Source

FEMS Microbiology Letters

Abstract

The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of Escherichia coli growth. NAG–thiazoline, at concentrations up to 1 mg/ml, was not found to affect the viability of E. coli DH5α.

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