IFN-alpha beta Mediated Inflammatory Responses and Antiviral Defense in Liver Is TLR9-Independent but MyD88-Dependent During Murine Cytomegalovirus Infection
viral;MCMV;TLR9;cyokine;leukocyte;liver;antiviral;murine cytomegalovirus infection
The American Association of Immunologists, Inc.
The Journal of Immunology
Chemokine responses critical for inflammation and promotion of effective innate control of murine CMV (MCMV) in liver have been shown to be dependent on immunoregulatory functions elicited by IFN-alpha beta. However, it remains to be determined whether upstream factors that promote viral sensing resulting in the rapid secretion of IFN-alpha beta in liver differ from those described in other tissues. Because plasmacytoid dendritic cells (pDCs) are known producers of high levels of systemic IFN-alpha beta in response to MCMV,this study examines the in vivo contribution of pDCs to IFN -alpha beta production in the liver, and whether production of the cytokine and ensuing inflammatory events are dependent on TLR9, MyD88, or both.