DigitalCommons@Bryant University

Title

Selectivity and Metaplasticity in a Unified Calcium-Dependent Model

Authors

Luk C. Yeung, Brown University
Brian S. Blais, Bryant University
Leon N. Cooper, Brown University
Harel Z. Shouval, Brown University

Document Type

Article

Comments

Published by MIT Press in Advances in Neural Information Processing Systems, Volume 15.

Abstract

A unified, biophysically motivated Calcium-Dependent Learning model has been shown to account for various rate-based and spike time-dependent paradigms for inducing synaptic plasticity. Here, we investigate the properties of this model for a multi-synapse neuron that receives inputs with different spike-train statistics. In addition, we present a physiological form of metaplasticity, an activity-driven regulation mechanism, that is essential for the robustness of the model. A neuron thus implemented develops stable and selective receptive fields, given various input statistics

Recommended Citation

Yeung, Luk C.; Blais, Brian S.; Cooper, Leon N.; and Shouval, Harel Z., "Selectivity and Metaplasticity in a Unified Calcium-Dependent Model" (2003). Science and Technology Faculty Journal Articles. Paper 12.
http://digitalcommons.bryant.edu/sci_jou/12