This paper investigates the relationship between inflation, trade, unemployment, education, and economic growth on income inequality in the South American OECD countries (Chile, Costa Rica, Colombia, Mexico, Argentina, Brazil, and Peru). While Argentina, Brazil, and Peru are not official OECD countries, they have a working relationship with OECD and have taken the first steps toward initiation in OECD. The variable that represents income inequality is the Gini Index World Bank estimator, and the variable that represents economic growth is GDP. This paper uses a panel data set from 2006 to 2020. The results of this study show that trade percentage, the unemployment percentage, and labor education increase income inequality, while inflation and GDP decrease income inequality.