This paper investigates the impact of determinants on the inflows of FDI to the Latin American and Caribbean region. The study incorporates cross-country information to describe incentives influencing flows of FDI into the region from 1992 - 2008. Factors are modeled using a least-squared regression model and are determined as significant. The results from the research and tests performed emphasize the correlation between specific economic indicators and flows of FDI. Using macro – level data from various sources, the results generally suggest that factors such as degree of openness and market size have a positive correlation with FDI flows; whereas, current account balance and unemployment negatively impact FDI flows to the region.