This paper dives into the socio-economic factors that lead to differences in U.S. State unemployment rates. The study will look at and evaluate prior economic literature, including regression analysis, comparative statistics, and raw data from the BLS and Census Bureau. Further, it will take select parts from past models to create and analyze an economic regression model. The data to be found below is a cross-sectional interpretation of each of the 50 states for the years 2000 & 2010. The root causes for fluctuations in unemployment can help economists better understand how to monitor and manage unemployment levels on a state by state basis.