Modeling Amblyopia Treatment Responses Through Principles of Synaptic Plasticity
amblyopia; visual impairment; synaptic plasticity; ophthalmology; treatment
Amblyopia is a common cause of visual impairment that results from unequal visual inputs during development. The imbalance is known to manifest through synaptic alterations in visual cortex that shift ocular dominance. Understanding the effects of amblyogenic drivers and their reversal with synaptic plasticity could enable improvements in amblyopia treatment efficacy. This study uses a specific model of activity-dependent neural plasticity, the Bienenstock, Cooper, and Munro (BCM) model, to compare the dynamics of amblyopia recovery at the neuronal level under several treatment protocols, including optical correction, patching, atropine penalization, and binocular therapies.