Title
Substrate Binding Affinity of Pseudomonas Aeruginosa Membrane-Bound Lytic Transglycosylase B by Hydrogen−Deuterium Exchange MALDI MS
Document Type
Article
Publisher
ACS Publications
Publication Source
Biochemistry
Abstract
Lytic transglycosylases cleave the β-(1→4)-glycosidic bond in the bacterial cell wall heteropolymer, peptidoglycan, between the N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues with the concomitant formation of a 1,6-anhydromuramoyl residue. With 72% amino acid sequence identity between the enzymes, the theoretical structure of the membrane-bound lytic transglycosylase B (MltB) from Psuedomonas aeruginosa was modeled on the known crystal structure of Escherichia coli Slt35, the soluble derivative of its MltB.
COinS
Comments
Published by ACS Publications in Biochemistry, Volume 43, pages 11275-11282.
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