Title

The Effect of NAG–thiazoline on Morphology and Surface Hydrophobicity of Escherichia Coli

Authors

Christopher W. Reid, Bryant University
Neil T. Blackburn
Anthony J. ClarkeFollow

Document Type

Article

Comments

Published by Wiley in FEMS Microbiology Letters Volume 234, Issue 2, pages 343-348.

Keywords

Escherichia coli;Morphology;NAG–thiazoline;Lytic transglycosylase;Penicillin-induced lysis;Autolysin

Publisher

Wiley

Publication Source

FEMS Microbiology Letters

Abstract

The β-hexosaminidase inhibitor and structural analog of the putative oxazolium reaction intermediate of lytic transglycosylases, N-acetylglucosamine thiazoline (NAG–thiazoline), was synthesized in 46% overall yield and tested as an inhibitor of Escherichia coli growth. NAG–thiazoline, at concentrations up to 1 mg/ml, was not found to affect the viability of E. coli DH5α.